Raft Pharmaceuticals is a startup biopharmaceutical company developing novel therapy targeting lipid rafts in inflamed and activated cells. Raft’s product, recombinant protein RFT1081 regulates cholesterol trafficking in the plasma membrane and normalizes clustered and cholesterol-overloaded lipid raft microdomains – specifically in inflamed glia and macrophages, relevant to the development of chronic pain states. Chronic pain is a major health problem affecting 20% of the population and 40% of older adults, having an extraordinary negative impact on quality of life. The annual cost of chronic pain is $635B. Opiates, NSAIDs, and anticonvulsants relieve pain for short intervals, but are less effective for chronic therapy, have serious side effects and potential for diversion and addiction (opioid epidemics). Animal testing shows the unprecedented efficacy of RFT1081 in models of chemotherapy- and nerve injury-induced neuropathic pain, as well as migraine.
Professor of Medicine at UC San Diego
Broad expertise in cholesterol metabolism and cellular mechanisms of inflammation. Discovered a new mechanism linking cholesterol and inflammation
Distinguished Professor of Anesthesiology at UC San Diego
Strong focus on spinal mechanisms of pain and analgesia. Significant experience in preclinical studies, performing pivotal small and large animal trials
Experienced entrepreneur in discovery and translation
Experienced biotech entrepreneur and executive
10225 Barnes Canyon Rd, San Diego, CA 92121, USA